Details of the Drug

General Information of Drug (ID: DMSWYF5)

Drug Name
Quinine
Synonyms
Aflukin; Chinin; Chinine; Chininum; Conchinin; Conquinine; Quindan; Quinidex; Quinidine; Quinimax; Quinina; Quinineanhydrous; Quinora; Quniacridine; Chinin [German]; Kinder Quinina; QUININE MONO HCL; Quinine Dab; Quinine [BAN]; Quinine anhydrous; Quinine bisulfate; Quinine sulfate; Quinine sulphate; Quinoline alkaloid; LT00645788;Q0028; SB01652; Beta-Quinine; Cin-Quin; Coco-Quinine; IBS-L0034250; Kinder Quinina (TN); Legatrin (TN); Quinine (BAN); Quinine, Anhydrous; Quinine, polymers; Quinine, tannate; Biquinate (*Bisulfate heptathydrate*); Dentojel (*Bisulfate heptathydrate*); Quinamm (*2:1 Sulfate salt*), dihydrate; Quine (*2:1 Sulfate salt*, dihydrate); Quinsan (*2:1 Sulfate salt*), dihydrate; Alpha-(6-Methoxy-4-quinoyl)-5-vinyl-2-quinclidinemethanol; Cinchonan-9-ol, 6'-methoxy-, (8.alpha.,9R)-, sulfate; (+)-Quinidine; (-)-Quinine; (1R)-(6-Methoxyquinolin-4-yl)((1S,4S,5R)-5-vinylquinuclidin-2-yl)methanol; (3A,8A,9r)-6'-methoxycinchonan-9-ol; (5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl)-(6-methoxyquinolin-4-yl)methanol; (8-alpha,9R)-6'-Methoxycinchonan-9-ol; (8.alpha.,9R)-6'-Methoxycinchonan-9-ol; (8S,9R)-6'-Methoxycinchonan-9-ol; (8S,9R)-Quinine; (9R)-6'-methoxy-8alpha-cinchonan-9-ol; (R)-(-)-Quinine, 6-methoxycinchonidine; (R)-(-)-quinine; (R)-(6-Methoxy-quinolin-4-yl)-((2S,5S)-5-vinyl-1-aza-bicyclo[2.2.2]oct-2-yl)-methanol; (R)-(6-methoxyquinolin-4-yl)((2S,4S,8R)-8-vinylquinuclidin-2-yl)methanol; (R)-[(2S,4R,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol; (R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol; (R)-[(2S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol; (S)-(5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl)-(6-methoxyquinolin-4-yl)methanol; (S)-[(2R,4R,5S)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol; 6'-Methoxycinchonan-9-ol; 6'-Methoxycinchonidine; 6'-Methoxycinchonine; 6-Methoxycinchonine
Indication
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Approved [1]
Therapeutic Class
Antimalarials
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL
#Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 324.4
Logarithm of the Partition Coefficient (xlogp) 2.9
Rotatable Bond Count (rotbonds) 4
Hydrogen Bond Donor Count (hbonddonor) 1
Hydrogen Bond Acceptor Count (hbondacc) 4
ADMET Property
Absorption
The absorption of drug is 76 - 88% []
BDDCS Class
Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 1: high solubility and high permeability [2]
Clearance
The apparent oral clearance of drug is 0.17 L/h/kg []
Elimination
12% of drug is excreted from urine in the unchanged form [2]
Half-life
The concentration or amount of drug in body reduced by one-half in 18 hours [3]
Metabolism
The drug is metabolized via the hepatic []
MRTD
The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 71.0697 micromolar/kg/day [4]
Unbound Fraction
The unbound fraction of drug in plasma is 0.3% [3]
Vd
The volume of distribution (Vd) of drug is 1.43 +/- 0.18 L/kg []
Water Solubility
The ability of drug to dissolve in water is measured as 111.1 mg/mL [2]
Chemical Identifiers
Formula
C20H24N2O2
IUPAC Name
(R)-[(2S,4S,5R)-5-ethenyl-1-azabicyclo[2.2.2]octan-2-yl]-(6-methoxyquinolin-4-yl)methanol
Canonical SMILES
COC1=CC2=C(C=CN=C2C=C1)[C@H]([C@@H]3C[C@@H]4CCN3C[C@@H]4C=C)O
InChI
InChI=1S/C20H24N2O2/c1-3-13-12-22-9-7-14(13)10-19(22)20(23)16-6-8-21-18-5-4-15(24-2)11-17(16)18/h3-6,8,11,13-14,19-20,23H,1,7,9-10,12H2,2H3/t13-,14-,19-,20+/m0/s1
InChIKey
LOUPRKONTZGTKE-WZBLMQSHSA-N
Cross-matching ID
PubChem CID
3034034
ChEBI ID
CHEBI:15854
CAS Number
72402-53-0
DrugBank ID
DB00468
TTD ID
D03DDR
VARIDT ID
DR00054
INTEDE ID
DR1385
ACDINA ID
D00577
Combinatorial Drugs (CBD) Click to Jump to the Detailed CBD Information of This Drug

Molecular Interaction Atlas of This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
E3 ubiquitin-protein ligase COP1 (RFWD2) TT05DLS COP1_HUMAN Modulator [5]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID MOA REF
Na(+)/Cl(-) betaine/GABA transporter (SLC6A12) DTBPTJF S6A12_HUMAN Substrate [6]
Organic cation/carnitine transporter 1 (SLC22A4) DT2EG60 S22A4_HUMAN Substrate [7]
Organic cation/carnitine transporter 2 (SLC22A5) DT3HUVD S22A5_HUMAN Substrate [8]
Organic cation transporter 1 (SLC22A1) DTT79CX S22A1_HUMAN Substrate [9]
Organic cation transporter 2 (SLC22A2) DT9IDPW S22A2_HUMAN Substrate [10]
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [11]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID MOA REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Substrate [12]
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Substrate [13]
Cytochrome P450 2C9 (CYP2C9) DE5IED8 CP2C9_HUMAN Substrate [14]
Mephenytoin 4-hydroxylase (CYP2C19) DEGTFWK CP2CJ_HUMAN Substrate [15]
Cytochrome P450 1A2 (CYP1A2) DEJGDUW CP1A2_HUMAN Substrate [16]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Substrate [17]
Cytochrome P450 2C8 (CYP2C8) DES5XRU CP2C8_HUMAN Substrate [18]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Substrate [17]

Drug Off-Target (DOT)
DOT Name DOT ID UniProt ID Interaction REF
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Regulation of Drug Effects [19]
Cytochrome P450 1A1 (CYP1A1) OTE4EFH8 CP1A1_HUMAN Gene/Protein Processing [20]
Cytochrome P450 1A2 (CYP1A2) OTLLBX48 CP1A2_HUMAN Gene/Protein Processing [20]
Cytochrome P450 2C19 (CYP2C19) OTFMJYYE CP2CJ_HUMAN Gene/Protein Processing [21]
Cytochrome P450 2C9 (CYP2C9) OTGLBN29 CP2C9_HUMAN Gene/Protein Processing [21]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Gene/Protein Processing [21]
Glutathione S-transferase Mu 1 (GSTM1) OTSBF2MO GSTM1_HUMAN Gene/Protein Processing [22]
Glutathione S-transferase P (GSTP1) OTLP0A0Y GSTP1_HUMAN Gene/Protein Processing [22]
Potassium voltage-gated channel subfamily H member 2 (KCNH2) OTZX881H KCNH2_HUMAN Gene/Protein Processing [23]
Sodium/hydrogen exchanger 7 (SLC9A7) OTVDLTYA SL9A7_HUMAN Gene/Protein Processing [24]
Molecular Interaction Atlas (MIA) Jump to Detail Molecular Interaction Atlas of This Drug

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Quinine
DDI Drug Name DDI Drug ID Severity Mechanism Disease REF
Lumefantrine DM29GAD Major Increased risk of prolong QT interval by the combination of Quinine and Lumefantrine. Malaria [1F40-1F45] [25]
Halofantrine DMOMK1V Major Increased risk of prolong QT interval by the combination of Quinine and Halofantrine. Malaria [1F40-1F45] [26]
Chloroquine DMSI5CB Major Increased risk of prolong QT interval by the combination of Quinine and Chloroquine. Malaria [1F40-1F45] [27]
Hydroxychloroquine DMSIVND Major Increased risk of prolong QT interval by the combination of Quinine and Hydroxychloroquine. Malaria [1F40-1F45] [27]
Primaquine DMWQ16I Moderate Increased risk of prolong QT interval by the combination of Quinine and Primaquine. Malaria [1F40-1F45] [28]
Coadministration of a Drug Treating the Disease Different from Quinine (Comorbidity)
DDI Drug Name DDI Drug ID Severity Mechanism Comorbidity REF
Repaglinide DM5SXUV Moderate Increased risk of hypoglycemia by the combination of Quinine and Repaglinide. Acute diabete complication [5A2Y] [29]
Glibenclamide DM8JXPZ Moderate Increased risk of hypoglycemia by the combination of Quinine and Glibenclamide. Acute diabete complication [5A2Y] [29]
Tolazamide DMIHRNA Moderate Increased risk of hypoglycemia by the combination of Quinine and Tolazamide. Acute diabete complication [5A2Y] [29]
Nateglinide DMLK2QH Moderate Increased risk of hypoglycemia by the combination of Quinine and Nateglinide. Acute diabete complication [5A2Y] [29]
Insulin-glulisine DMQI0FU Moderate Increased risk of hypoglycemia by the combination of Quinine and Insulin-glulisine. Acute diabete complication [5A2Y] [29]
Insulin-aspart DMX7V28 Moderate Increased risk of hypoglycemia by the combination of Quinine and Insulin-aspart. Acute diabete complication [5A2Y] [30]
Glipizide DMZA5PQ Moderate Increased risk of hypoglycemia by the combination of Quinine and Glipizide. Acute diabete complication [5A2Y] [29]
Ivosidenib DM8S6T7 Major Increased risk of prolong QT interval by the combination of Quinine and Ivosidenib. Acute myeloid leukaemia [2A60] [31]
Midostaurin DMI6E0R Moderate Increased risk of prolong QT interval by the combination of Quinine and Midostaurin. Acute myeloid leukaemia [2A60] [28]
Idarubicin DMM0XGL Moderate Decreased clearance of Quinine due to the transporter inhibition by Idarubicin. Acute myeloid leukaemia [2A60] [32]
Daunorubicin DMQUSBT Moderate Decreased clearance of Quinine due to the transporter inhibition by Daunorubicin. Acute myeloid leukaemia [2A60] [32]
Arn-509 DMT81LZ Moderate Increased metabolism of Quinine caused by Arn-509 mediated induction of CYP450 enzyme. Acute myeloid leukaemia [2A60] [33]
Gilteritinib DMTI0ZO Moderate Increased risk of prolong QT interval by the combination of Quinine and Gilteritinib. Acute myeloid leukaemia [2A60] [34]
Oliceridine DM6MDCF Moderate Increased risk of prolong QT interval by the combination of Quinine and Oliceridine. Acute pain [MG31] [28]
Mitotane DMU1GX0 Moderate Increased metabolism of Quinine caused by Mitotane mediated induction of CYP450 enzyme. Adrenal cancer [2D11] [33]
Galantamine DMEO794 Moderate Decreased metabolism of Quinine caused by Galantamine mediated inhibition of CYP450 enzyme. Alzheimer disease [8A20] [35]
Rivastigmine DMG629M Moderate Increased risk of ventricular arrhythmias by the combination of Quinine and Rivastigmine. Alzheimer disease [8A20] [28]
Donepezil DMIYG7Z Minor Decreased metabolism of Quinine caused by Donepezil mediated inhibition of CYP450 enzyme. Alzheimer disease [8A20] [36]
Metronidazole DMTIVEN Minor Increased risk of prolong QT interval by the combination of Quinine and Metronidazole. Amoebiasis [1A36] [25]
Ivabradine DM0L594 Major Increased risk of ventricular arrhythmias by the combination of Quinine and Ivabradine. Angina pectoris [BA40] [37]
Bepridil DM0RKS4 Major Increased risk of prolong QT interval by the combination of Quinine and Bepridil. Angina pectoris [BA40] [28]
Dronedarone DMA8FS5 Major Increased risk of prolong QT interval by the combination of Quinine and Dronedarone. Angina pectoris [BA40] [28]
Bedaquiline DM3906J Major Increased risk of prolong QT interval by the combination of Quinine and Bedaquiline. Antimicrobial drug resistance [MG50-MG52] [38]
Methylphenobarbital DMDSWAG Moderate Increased metabolism of Quinine caused by Methylphenobarbital mediated induction of CYP450 enzyme. Anxiety disorder [6B00-6B0Z] [33]
Hydroxyzine DMF8Y74 Moderate Increased risk of prolong QT interval by the combination of Quinine and Hydroxyzine. Anxiety disorder [6B00-6B0Z] [28]
Voriconazole DMAOL2S Moderate Decreased metabolism of Quinine caused by Voriconazole mediated inhibition of CYP450 enzyme. Aspergillosis [1F20] [25]
Posaconazole DMUL5EW Moderate Decreased metabolism of Quinine caused by Posaconazole mediated inhibition of CYP450 enzyme. Aspergillosis [1F20] [25]
Levalbuterol DM5YBO1 Moderate Increased risk of prolong QT interval by the combination of Quinine and Levalbuterol. Asthma [CA23] [39]
Terbutaline DMD4381 Moderate Increased risk of ventricular arrhythmias by the combination of Quinine and Terbutaline. Asthma [CA23] [40]
Pirbuterol DMI5678 Moderate Increased risk of prolong QT interval by the combination of Quinine and Pirbuterol. Asthma [CA23] [40]
Salbutamol DMN9CWF Moderate Increased risk of prolong QT interval by the combination of Quinine and Salbutamol. Asthma [CA23] [39]
Formoterol DMSOURV Moderate Increased risk of prolong QT interval by the combination of Quinine and Formoterol. Asthma [CA23] [40]
Lisdexamfetamine DM6W8V5 Moderate Increased risk of prolong QT interval by the combination of Quinine and Lisdexamfetamine. Attention deficit hyperactivity disorder [6A05] [37]
Desipramine DMT2FDC Moderate Increased risk of prolong QT interval by the combination of Quinine and Desipramine. Attention deficit hyperactivity disorder [6A05] [28]
Ofloxacin DM0VQN3 Moderate Increased risk of prolong QT interval by the combination of Quinine and Ofloxacin. Bacterial infection [1A00-1C4Z] [41]
Ciprofloxacin XR DM2NLS9 Moderate Increased risk of prolong QT interval by the combination of Quinine and Ciprofloxacin XR. Bacterial infection [1A00-1C4Z] [28]
Dalfopristin DM4LTKV Moderate Decreased metabolism of Quinine caused by Dalfopristin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [25]
Clarithromycin DM4M1SG Major Decreased metabolism of Quinine caused by Clarithromycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [42]
Sulfamethoxazole DMB08GE Minor Increased risk of prolong QT interval by the combination of Quinine and Sulfamethoxazole. Bacterial infection [1A00-1C4Z] [28]
Sparfloxacin DMB4HCT Major Increased risk of prolong QT interval by the combination of Quinine and Sparfloxacin. Bacterial infection [1A00-1C4Z] [41]
Gemifloxacin DMHT34O Moderate Increased risk of prolong QT interval by the combination of Quinine and Gemifloxacin. Bacterial infection [1A00-1C4Z] [41]
Levofloxacin DMS60RB Moderate Increased risk of prolong QT interval by the combination of Quinine and Levofloxacin. Bacterial infection [1A00-1C4Z] [41]
Troleandomycin DMUZNIG Major Decreased metabolism of Quinine caused by Troleandomycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [42]
Lomefloxacin DMVRH9C Moderate Increased risk of prolong QT interval by the combination of Quinine and Lomefloxacin. Bacterial infection [1A00-1C4Z] [28]
Telithromycin DMZ4P3A Major Decreased metabolism of Quinine caused by Telithromycin mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [42]
Tetracycline DMZA017 Minor Decreased metabolism of Quinine caused by Tetracycline mediated inhibition of CYP450 enzyme. Bacterial infection [1A00-1C4Z] [43]
Retigabine DMGNYIH Moderate Increased risk of prolong QT interval by the combination of Quinine and Retigabine. Behcet disease [4A62] [28]
Pexidartinib DMS2J0Z Moderate Increased metabolism of Quinine caused by Pexidartinib mediated induction of CYP450 enzyme. Bone/articular cartilage neoplasm [2F7B] [33]
Loperamide DMOJZQ9 Major Increased risk of prolong QT interval by the combination of Quinine and Loperamide. Bowel habit change [ME05] [44]
Eribulin DM1DX4Q Moderate Increased risk of prolong QT interval by the combination of Quinine and Eribulin. Breast cancer [2C60-2C6Y] [28]
Talazoparib DM1KS78 Moderate Decreased clearance of Quinine due to the transporter inhibition by Talazoparib. Breast cancer [2C60-2C6Y] [45]
Lapatinib DM3BH1Y Moderate Increased risk of prolong QT interval by the combination of Quinine and Lapatinib. Breast cancer [2C60-2C6Y] [28]
Tucatinib DMBESUA Moderate Decreased metabolism of Quinine caused by Tucatinib mediated inhibition of CYP450 enzyme. Breast cancer [2C60-2C6Y] [25]
Toremifene DMQYUWG Major Increased risk of prolong QT interval by the combination of Quinine and Toremifene. Breast cancer [2C60-2C6Y] [28]
Bosutinib DMTI8YE Moderate Decreased clearance of Quinine due to the transporter inhibition by Bosutinib. Breast cancer [2C60-2C6Y] [37]
Sotalol DML60TN Major Increased risk of prolong QT interval by the combination of Quinine and Sotalol. Cardiac arrhythmia [BC9Z] [28]
PF-04449913 DMSB068 Moderate Increased risk of prolong QT interval by the combination of Quinine and PF-04449913. Chronic myelomonocytic leukaemia [2A40] [46]
Olodaterol DM62B78 Moderate Increased risk of prolong QT interval by the combination of Quinine and Olodaterol. Chronic obstructive pulmonary disease [CA22] [40]
Vilanterol DMF5EK1 Moderate Increased risk of prolong QT interval by the combination of Quinine and Vilanterol. Chronic obstructive pulmonary disease [CA22] [39]
Salmeterol DMIEU69 Moderate Increased risk of ventricular arrhythmias by the combination of Quinine and Salmeterol. Chronic obstructive pulmonary disease [CA22] [40]
Indacaterol DMQJHR7 Moderate Increased risk of ventricular arrhythmias by the combination of Quinine and Indacaterol. Chronic obstructive pulmonary disease [CA22] [40]
Arformoterol DMYM974 Moderate Increased risk of prolong QT interval by the combination of Quinine and Arformoterol. Chronic obstructive pulmonary disease [CA22] [40]
Phenylbutazone DMAYL0T Moderate Increased metabolism of Quinine caused by Phenylbutazone mediated induction of CYP450 enzyme. Chronic pain [MG30] [33]
Fidaxomicin DMFP6MV Minor Decreased clearance of Quinine due to the transporter inhibition by Fidaxomicin. Clostridium difficile enterocolitis [1A04] [47]
Oxaliplatin DMQNWRD Moderate Increased risk of prolong QT interval by the combination of Quinine and Oxaliplatin. Colorectal cancer [2B91] [28]
Isoproterenol DMK7MEY Moderate Increased risk of prolong QT interval by the combination of Quinine and Isoproterenol. Conduction disorder [BC63] [39]
Halothane DM80OZ5 Moderate Increased risk of prolong QT interval by the combination of Quinine and Halothane. Corneal disease [9A76-9A78] [28]
Propofol DMB4OLE Moderate Increased risk of prolong QT interval by the combination of Quinine and Propofol. Corneal disease [9A76-9A78] [48]
Sevoflurane DMC9O43 Moderate Increased risk of prolong QT interval by the combination of Quinine and Sevoflurane. Corneal disease [9A76-9A78] [28]
Probucol DMVZQ2M Moderate Increased risk of prolong QT interval by the combination of Quinine and Probucol. Coronary atherosclerosis [BA80] [28]
Dextromethorphan DMUDJZM Moderate Decreased metabolism of Quinine caused by Dextromethorphan mediated inhibition of CYP450 enzyme. Cough [MD12] [25]
Clofazimine DMEBOFW Moderate Increased risk of prolong QT interval by the combination of Quinine and Clofazimine. Crohn disease [DD70] [49]
Mifepristone DMGZQEF Major Increased risk of prolong QT interval by the combination of Quinine and Mifepristone. Cushing syndrome [5A70] [28]
Pasireotide DMHM7JS Major Increased risk of prolong QT interval by the combination of Quinine and Pasireotide. Cushing syndrome [5A70] [28]
Osilodrostat DMIJC9X Moderate Increased risk of prolong QT interval by the combination of Quinine and Osilodrostat. Cushing syndrome [5A70] [37]
Lumacaftor DMCLWDJ Moderate Increased metabolism of Quinine caused by Lumacaftor mediated induction of CYP450 enzyme. Cystic fibrosis [CA25] [33]
MK-8228 DMOB58Q Moderate Decreased metabolism of Quinine caused by MK-8228 mediated inhibition of CYP450 enzyme. Cytomegaloviral disease [1D82] [25]
Rivaroxaban DMQMBZ1 Moderate Decreased clearance of Quinine due to the transporter inhibition by Rivaroxaban. Deep vein thrombosis [BD71] [50]
Sertraline DM0FB1J Moderate Increased risk of prolong QT interval by the combination of Quinine and Sertraline. Depression [6A70-6A7Z] [28]
Trimipramine DM1SC8M Moderate Increased risk of prolong QT interval by the combination of Quinine and Trimipramine. Depression [6A70-6A7Z] [28]
Fluoxetine DM3PD2C Moderate Increased risk of prolong QT interval by the combination of Quinine and Fluoxetine. Depression [6A70-6A7Z] [28]
Nortriptyline DM4KDYJ Moderate Increased risk of prolong QT interval by the combination of Quinine and Nortriptyline. Depression [6A70-6A7Z] [28]
Nefazodone DM4ZS8M Moderate Decreased metabolism of Quinine caused by Nefazodone mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [25]
Duloxetine DM9BI7M Moderate Decreased metabolism of Quinine caused by Duloxetine mediated inhibition of CYP450 enzyme. Depression [6A70-6A7Z] [51]
Escitalopram DMFK9HG Major Increased risk of prolong QT interval by the combination of Quinine and Escitalopram. Depression [6A70-6A7Z] [28]
Clomipramine DMINRKW Moderate Increased risk of prolong QT interval by the combination of Quinine and Clomipramine. Depression [6A70-6A7Z] [28]
Trazodone DMK1GBJ Moderate Increased risk of prolong QT interval by the combination of Quinine and Trazodone. Depression [6A70-6A7Z] [52]
Amoxapine DMKITQE Moderate Increased risk of prolong QT interval by the combination of Quinine and Amoxapine. Depression [6A70-6A7Z] [28]
Maprotiline DMPWB7T Moderate Increased risk of prolong QT interval by the combination of Quinine and Maprotiline. Depression [6A70-6A7Z] [28]
Tetrabenazine DMYWQ0O Moderate Increased risk of prolong QT interval by the combination of Quinine and Tetrabenazine. Dissociative neurological symptom disorder [6B60] [28]
Deutetrabenazine DMUPFLI Moderate Additive CNS depression effects by the combination of Quinine and Deutetrabenazine. Dystonic disorder [8A02] [53]
Ingrezza DMVPLNC Moderate Additive CNS depression effects by the combination of Quinine and Ingrezza. Dystonic disorder [8A02] [54]
Primidone DM0WX6I Moderate Increased metabolism of Quinine caused by Primidone mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [33]
Felbamate DM1V5ZS Moderate Increased metabolism of Quinine caused by Felbamate mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [33]
Oxcarbazepine DM5PU6O Moderate Increased metabolism of Quinine caused by Oxcarbazepine mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [33]
Cenobamate DM8KLU9 Moderate Increased metabolism of Quinine caused by Cenobamate mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [33]
Fosphenytoin DMOX3LB Moderate Increased metabolism of Quinine caused by Fosphenytoin mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [33]
Rufinamide DMWE60C Moderate Increased metabolism of Quinine caused by Rufinamide mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [33]
Phenobarbital DMXZOCG Moderate Increased metabolism of Quinine caused by Phenobarbital mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [55]
Carbamazepine DMZOLBI Moderate Increased metabolism of Quinine caused by Carbamazepine mediated induction of CYP450 enzyme. Epilepsy/seizure [8A61-8A6Z] [55]
Tazemetostat DMWP1BH Moderate Increased metabolism of Quinine caused by Tazemetostat mediated induction of CYP450 enzyme. Follicular lymphoma [2A80] [33]
Solifenacin DMG592Q Moderate Increased risk of prolong QT interval by the combination of Quinine and Solifenacin. Functional bladder disorder [GC50] [28]
Tolterodine DMSHPW8 Minor Decreased metabolism of Quinine caused by Tolterodine mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [56]
Darifenacin DMWXLYZ Moderate Decreased metabolism of Quinine caused by Darifenacin mediated inhibition of CYP450 enzyme. Functional bladder disorder [GC50] [57]
Itraconazole DMCR1MV Moderate Decreased metabolism of Quinine caused by Itraconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [25]
Pentamidine DMHZJCG Moderate Increased risk of prolong QT interval by the combination of Quinine and Pentamidine. Fungal infection [1F29-1F2F] [28]
Miconazole DMPMYE8 Moderate Decreased metabolism of Quinine caused by Miconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [25]
Ketoconazole DMPZI3Q Moderate Decreased metabolism of Quinine caused by Ketoconazole mediated inhibition of CYP450 enzyme. Fungal infection [1F29-1F2F] [25]
Cisapride DMY7PED Major Increased risk of prolong QT interval by the combination of Quinine and Cisapride. Gastro-oesophageal reflux disease [DA22] [28]
Ripretinib DM958QB Moderate Decreased clearance of Quinine due to the transporter inhibition by Ripretinib. Gastrointestinal stromal tumour [2B5B] [25]
Sunitinib DMCBJSR Moderate Increased risk of prolong QT interval by the combination of Quinine and Sunitinib. Gastrointestinal stromal tumour [2B5B] [28]
Boceprevir DMBSHMF Moderate Decreased metabolism of Quinine caused by Boceprevir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [25]
Telaprevir DMMRV29 Moderate Decreased metabolism of Quinine caused by Telaprevir mediated inhibition of CYP450 enzyme. Hepatitis virus infection [1E50-1E51] [25]
Rifampin DMA8J1G Major Increased metabolism of Quinine caused by Rifampin mediated induction of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [58]
Rifapentine DMCHV4I Moderate Increased metabolism of Quinine caused by Rifapentine mediated induction of CYP450 enzyme. HIV-infected patients with tuberculosis [1B10-1B14] [33]
Brentuximab vedotin DMWLC57 Moderate Decreased clearance of Quinine due to the transporter inhibition by Brentuximab vedotin. Hodgkin lymphoma [2B30] [59]
Delavirdine DM3NF5G Moderate Decreased metabolism of Quinine caused by Delavirdine mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [25]
Fosamprenavir DM4W9B3 Moderate Decreased metabolism of Quinine caused by Fosamprenavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [25]
Fostemsavir DM50ILT Moderate Increased risk of prolong QT interval by the combination of Quinine and Fostemsavir. Human immunodeficiency virus disease [1C60-1C62] [60]
Cobicistat DM6L4H2 Moderate Decreased metabolism of Quinine caused by Cobicistat mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [25]
Efavirenz DMC0GSJ Major Increased risk of prolong QT interval by the combination of Quinine and Efavirenz. Human immunodeficiency virus disease [1C60-1C62] [61]
Saquinavir DMG814N Major Increased risk of prolong QT interval by the combination of Quinine and Saquinavir. Human immunodeficiency virus disease [1C60-1C62] [62]
Etravirine DMGV8QU Moderate Increased metabolism of Quinine caused by Etravirine mediated induction of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [33]
Rilpivirine DMJ0QOW Moderate Increased risk of prolong QT interval by the combination of Quinine and Rilpivirine. Human immunodeficiency virus disease [1C60-1C62] [28]
Amprenavir DMLMXE0 Moderate Decreased metabolism of Quinine caused by Amprenavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [25]
Darunavir DMN3GCH Moderate Decreased metabolism of Quinine caused by Darunavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [25]
Atazanavir DMSYRBX Moderate Decreased metabolism of Quinine caused by Atazanavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [25]
Ritonavir DMU764S Major Decreased metabolism of Quinine caused by Ritonavir mediated inhibition of CYP450 enzyme. Human immunodeficiency virus disease [1C60-1C62] [63]
Aliskiren DM1BV7W Moderate Decreased clearance of Quinine due to the transporter inhibition by Aliskiren. Hypertension [BA00-BA04] [28]
Verapamil DMA7PEW Moderate Decreased metabolism of Quinine caused by Verapamil mediated inhibition of CYP450 enzyme. Hypertension [BA00-BA04] [25]
Conivaptan DM1V329 Moderate Decreased metabolism of Quinine caused by Conivaptan mediated inhibition of CYP450 enzyme. Hypo-osmolality/hyponatraemia [5C72] [25]
Tolvaptan DMIWFRL Moderate Decreased clearance of Quinine due to the transporter inhibition by Tolvaptan. Hypo-osmolality/hyponatraemia [5C72] [64]
Berotralstat DMWA2DZ Major Decreased clearance of Quinine due to the transporter inhibition by Berotralstat. Innate/adaptive immunodeficiency [4A00] [65]
Amobarbital DM0GQ8N Moderate Increased metabolism of Quinine caused by Amobarbital mediated induction of CYP450 enzyme. Insomnia [7A00-7A0Z] [33]
Polyethylene glycol DM4I1JP Major Increased risk of ventricular arrhythmias by the combination of Quinine and Polyethylene glycol. Irritable bowel syndrome [DD91] [66]
Phenolphthalein DM5SICT Moderate Increased risk of ventricular arrhythmias by the combination of Quinine and Phenolphthalein. Irritable bowel syndrome [DD91] [28]
Naloxegol DML0B41 Minor Decreased metabolism of Quinine caused by Naloxegol mediated inhibition of CYP450 enzyme. Large intestine motility disorder [DB32] [67]
Crizotinib DM4F29C Major Increased risk of prolong QT interval by the combination of Quinine and Crizotinib. Lung cancer [2C25] [68]
Brigatinib DM7W94S Moderate Increased metabolism of Quinine caused by Brigatinib mediated induction of CYP450 enzyme. Lung cancer [2C25] [69]
Porfimer Sodium DM7ZWNY Moderate Increased risk of photosensitivity reactions by the combination of Quinine and Porfimer Sodium. Lung cancer [2C25] [70]
Ceritinib DMB920Z Major Increased risk of prolong QT interval by the combination of Quinine and Ceritinib. Lung cancer [2C25] [28]
PF-06463922 DMKM7EW Moderate Increased metabolism of Quinine caused by PF-06463922 mediated induction of CYP450 enzyme. Lung cancer [2C25] [33]
Osimertinib DMRJLAT Major Increased risk of prolong QT interval by the combination of Quinine and Osimertinib. Lung cancer [2C25] [71]
Selpercatinib DMZR15V Major Increased risk of prolong QT interval by the combination of Quinine and Selpercatinib. Lung cancer [2C25] [37]
Inotuzumab ozogamicin DMAC130 Moderate Increased risk of prolong QT interval by the combination of Quinine and Inotuzumab ozogamicin. Malignant haematopoietic neoplasm [2B33] [37]
Idelalisib DM602WT Moderate Decreased metabolism of Quinine caused by Idelalisib mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [72]
GDC-0199 DMH0QKA Major Decreased clearance of Quinine due to the transporter inhibition by GDC-0199. Mature B-cell leukaemia [2A82] [25]
IPI-145 DMWA24P Moderate Decreased metabolism of Quinine caused by IPI-145 mediated inhibition of CYP450 enzyme. Mature B-cell leukaemia [2A82] [25]
Arsenic trioxide DM61TA4 Major Increased risk of prolong QT interval by the combination of Quinine and Arsenic trioxide. Mature B-cell lymphoma [2A85] [73]
Arry-162 DM1P6FR Moderate Decreased clearance of Quinine due to the transporter inhibition by Arry-162. Melanoma [2C30] [25]
Vemurafenib DM62UG5 Major Increased risk of prolong QT interval by the combination of Quinine and Vemurafenib. Melanoma [2C30] [28]
LGX818 DMNQXV8 Moderate Increased risk of prolong QT interval by the combination of Quinine and LGX818. Melanoma [2C30] [74]
Dabrafenib DMX6OE3 Moderate Increased metabolism of Quinine caused by Dabrafenib mediated induction of CYP450 enzyme. Melanoma [2C30] [33]
Ubrogepant DM749I3 Moderate Decreased clearance of Quinine due to the transporter inhibition by Ubrogepant. Migraine [8A80] [75]
Exjade DMHPRWG Moderate Decreased metabolism of Quinine caused by Exjade mediated inhibition of CYP450 enzyme. Mineral absorption/transport disorder [5C64] [76]
Panobinostat DM58WKG Major Increased risk of prolong QT interval by the combination of Quinine and Panobinostat. Multiple myeloma [2A83] [77]
Thalidomide DM70BU5 Moderate Increased risk of ventricular arrhythmias by the combination of Quinine and Thalidomide. Multiple myeloma [2A83] [25]
Siponimod DM2R86O Major Increased risk of ventricular arrhythmias by the combination of Quinine and Siponimod. Multiple sclerosis [8A40] [25]
Fingolimod DM5JVAN Major Increased risk of ventricular arrhythmias by the combination of Quinine and Fingolimod. Multiple sclerosis [8A40] [28]
Ozanimod DMT6AM2 Major Increased risk of ventricular arrhythmias by the combination of Quinine and Ozanimod. Multiple sclerosis [8A40] [78]
Rifabutin DM1YBHK Moderate Increased metabolism of Quinine caused by Rifabutin mediated induction of CYP450 enzyme. Mycobacterium infection [1B10-1B21] [33]
Fedratinib DM4ZBK6 Moderate Decreased metabolism of Quinine caused by Fedratinib mediated inhibition of CYP450 enzyme. Myeloproliferative neoplasm [2A20] [25]
Dasatinib DMJV2EK Moderate Increased risk of prolong QT interval by the combination of Quinine and Dasatinib. Myeloproliferative neoplasm [2A20] [79]
Modafinil DMYILBE Minor Increased metabolism of Quinine caused by Modafinil mediated induction of CYP450 enzyme. Narcolepsy [7A20] [80]
Promethazine DM6I5GR Moderate Increased risk of prolong QT interval by the combination of Quinine and Promethazine. Nausea/vomiting [MD90] [28]
Granisetron DMIUW25 Moderate Increased risk of prolong QT interval by the combination of Quinine and Granisetron. Nausea/vomiting [MD90] [28]
Ondansetron DMOTQ1I Moderate Increased risk of prolong QT interval by the combination of Quinine and Ondansetron. Nausea/vomiting [MD90] [28]
Entrectinib DMMPTLH Moderate Increased risk of prolong QT interval by the combination of Quinine and Entrectinib. Non-small cell lung cancer [2C25] [25]
Levomethadyl Acetate DM06HG5 Major Increased risk of prolong QT interval by the combination of Quinine and Levomethadyl Acetate. Opioid use disorder [6C43] [37]
Lofexidine DM1WXA6 Moderate Increased risk of prolong QT interval by the combination of Quinine and Lofexidine. Opioid use disorder [6C43] [28]
S-297995 DM26IH8 Moderate Decreased metabolism of Quinine caused by S-297995 mediated inhibition of CYP450 enzyme. Opioid use disorder [6C43] [37]
Rucaparib DM9PVX8 Moderate Increased risk of prolong QT interval by the combination of Quinine and Rucaparib. Ovarian cancer [2C73] [28]
MK-4827 DMLYGH4 Moderate Decreased clearance of Quinine due to the transporter inhibition by MK-4827. Ovarian cancer [2C73] [81]
Dextropropoxyphene DM23HCX Moderate Increased risk of prolong QT interval by the combination of Quinine and Dextropropoxyphene. Pain [MG30-MG3Z] [82]
Prilocaine DMI7DZ2 Major Increased risk of methemoglobinemia by the combination of Quinine and Prilocaine. Pain [MG30-MG3Z] [83]
Buprenorphine DMPRI8G Moderate Increased risk of prolong QT interval by the combination of Quinine and Buprenorphine. Pain [MG30-MG3Z] [28]
Triclabendazole DMPWGBR Moderate Increased risk of prolong QT interval by the combination of Quinine and Triclabendazole. Parasitic worm infestation [1F90] [28]
Pimavanserin DMR7IVC Moderate Increased risk of prolong QT interval by the combination of Quinine and Pimavanserin. Parkinsonism [8A00] [84]
Abametapir DM2RX0I Moderate Decreased metabolism of Quinine caused by Abametapir mediated inhibition of CYP450 enzyme. Pediculosis [1G00] [85]
Famotidine DMRL3AB Moderate Increased risk of prolong QT interval by the combination of Quinine and Famotidine. Peptic ulcer [DA61] [25]
Macimorelin DMQYJIR Major Increased risk of prolong QT interval by the combination of Quinine and Macimorelin. Pituitary gland disorder [5A60-5A61] [86]
Lefamulin DME6G97 Major Increased risk of prolong QT interval by the combination of Quinine and Lefamulin. Pneumonia [CA40] [87]
Lonafarnib DMGM2Z6 Moderate Decreased metabolism of Quinine caused by Lonafarnib mediated inhibition of CYP450 enzyme. Premature ageing appearance [LD2B] [25]
Ritodrine DM4V6RL Moderate Increased risk of prolong QT interval by the combination of Quinine and Ritodrine. Preterm labour/delivery [JB00] [40]
Degarelix DM3O8QY Moderate Increased risk of prolong QT interval by the combination of Quinine and Degarelix. Prostate cancer [2C82] [37]
ABIRATERONE DM8V75C Moderate Increased risk of prolong QT interval by the combination of Quinine and ABIRATERONE. Prostate cancer [2C82] [37]
Nilutamide DMFN07X Moderate Increased risk of prolong QT interval by the combination of Quinine and Nilutamide. Prostate cancer [2C82] [37]
Enzalutamide DMGL19D Moderate Increased metabolism of Quinine caused by Enzalutamide mediated induction of CYP450 enzyme. Prostate cancer [2C82] [33]
Flutamide DMK0O7U Moderate Increased risk of prolong QT interval by the combination of Quinine and Flutamide. Prostate cancer [2C82] [37]
Relugolix DMK7IWL Major Decreased metabolism of Quinine caused by Relugolix mediated inhibition of CYP450 enzyme. Prostate cancer [2C82] [88]
Bicalutamide DMZMSPF Moderate Increased risk of prolong QT interval by the combination of Quinine and Bicalutamide. Prostate cancer [2C82] [37]
Silodosin DMJSBT6 Moderate Decreased clearance of Quinine due to the transporter inhibition by Silodosin. Prostate hyperplasia [GA90] [89]
Levomepromazine DMIKFEL Moderate Increased risk of prolong QT interval by the combination of Quinine and Levomepromazine. Psychotic disorder [6A20-6A25] [28]
Fluphenazine DMIT8LX Moderate Increased risk of prolong QT interval by the combination of Quinine and Fluphenazine. Psychotic disorder [6A20-6A25] [28]
Triflupromazine DMKFQJP Moderate Increased risk of prolong QT interval by the combination of Quinine and Triflupromazine. Psychotic disorder [6A20-6A25] [28]
Bosentan DMIOGBU Moderate Increased metabolism of Quinine caused by Bosentan mediated induction of CYP450 enzyme. Pulmonary hypertension [BB01] [33]
Riociguat DMXBLMP Moderate Decreased clearance of Quinine due to the transporter inhibition by Riociguat. Pulmonary hypertension [BB01] [25]
Temsirolimus DMS104F Moderate Increased plasma concentrations of Quinine and Temsirolimus due to competitive inhibition of the same metabolic pathway. Renal cell carcinoma [2C90] [90]
Gatifloxacin DMSL679 Major Increased risk of prolong QT interval by the combination of Quinine and Gatifloxacin. Respiratory infection [CA07-CA4Z] [91]
Dexamethasone DMMWZET Moderate Increased metabolism of Quinine caused by Dexamethasone mediated induction of CYP450 enzyme. Rheumatoid arthritis [FA20] [33]
Nafcillin DMN9RPO Moderate Increased metabolism of Quinine caused by Nafcillin mediated induction of CYP450 enzyme. Rheumatoid arthritis [FA20] [33]
Quetiapine DM1N62C Moderate Increased risk of prolong QT interval by the combination of Quinine and Quetiapine. Schizophrenia [6A20] [28]
Mesoridazine DM2ZGAN Major Increased risk of prolong QT interval by the combination of Quinine and Mesoridazine. Schizophrenia [6A20] [28]
Thioridazine DM35M8J Major Decreased metabolism of Quinine caused by Thioridazine mediated inhibition of CYP450 enzyme. Schizophrenia [6A20] [92]
Aripiprazole DM3NUMH Moderate Decreased metabolism of Quinine caused by Aripiprazole mediated inhibition of CYP450 enzyme. Schizophrenia [6A20] [93]
Iloperidone DM6AUFY Major Increased risk of prolong QT interval by the combination of Quinine and Iloperidone. Schizophrenia [6A20] [28]
Paliperidone DM7NPJS Moderate Increased risk of prolong QT interval by the combination of Quinine and Paliperidone. Schizophrenia [6A20] [28]
Haloperidol DM96SE0 Major Increased risk of prolong QT interval by the combination of Quinine and Haloperidol. Schizophrenia [6A20] [28]
Perphenazine DMA4MRX Moderate Increased risk of prolong QT interval by the combination of Quinine and Perphenazine. Schizophrenia [6A20] [28]
Chlorpromazine DMBGZI3 Moderate Increased risk of prolong QT interval by the combination of Quinine and Chlorpromazine. Schizophrenia [6A20] [28]
Trifluoperazine DMKBYWI Moderate Increased risk of prolong QT interval by the combination of Quinine and Trifluoperazine. Schizophrenia [6A20] [28]
Risperidone DMN6DXL Moderate Increased risk of prolong QT interval by the combination of Quinine and Risperidone. Schizophrenia [6A20] [28]
Amisulpride DMSJVAM Major Increased risk of prolong QT interval by the combination of Quinine and Amisulpride. Schizophrenia [6A20] [94]
Asenapine DMSQZE2 Moderate Increased risk of prolong QT interval by the combination of Quinine and Asenapine. Schizophrenia [6A20] [28]
Vardenafil DMTBGW8 Moderate Increased risk of prolong QT interval by the combination of Quinine and Vardenafil. Sexual dysfunction [HA00-HA01] [28]
Voxelotor DMCS6M5 Moderate Decreased metabolism of Quinine caused by Voxelotor mediated inhibition of CYP450 enzyme. Sickle-cell disorder [3A51] [25]
Telotristat ethyl DMDIYFZ Moderate Increased metabolism of Quinine caused by Telotristat ethyl mediated induction of CYP450 enzyme. Small intestine developmental anomaly [DA90] [37]
Larotrectinib DM26CQR Moderate Decreased metabolism of Quinine caused by Larotrectinib mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [25]
Docetaxel DMDI269 Moderate Decreased clearance of Quinine due to the transporter inhibition by Docetaxel. Solid tumour/cancer [2A00-2F9Z] [95]
Armodafinil DMGB035 Minor Increased metabolism of Quinine caused by Armodafinil mediated induction of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [80]
LEE011 DMMX75K Major Decreased metabolism of Quinine caused by LEE011 mediated inhibition of CYP450 enzyme. Solid tumour/cancer [2A00-2F9Z] [28]
Vandetanib DMRICNP Major Increased risk of prolong QT interval by the combination of Quinine and Vandetanib. Solid tumour/cancer [2A00-2F9Z] [28]
Triptorelin DMTK4LS Moderate Increased risk of prolong QT interval by the combination of Quinine and Triptorelin. Solid tumour/cancer [2A00-2F9Z] [37]
Taxol DMUOT9V Moderate Decreased clearance of Quinine due to the transporter inhibition by Taxol. Solid tumour/cancer [2A00-2F9Z] [95]
Doxorubicin DMVP5YE Moderate Increased risk of prolong QT interval by the combination of Quinine and Doxorubicin. Solid tumour/cancer [2A00-2F9Z] [28]
Telavancin DM58VQX Moderate Increased risk of prolong QT interval by the combination of Quinine and Telavancin. Staphylococcal/streptococcal disease [1B5Y] [28]
Adenosine DMM2NSK Major Increased risk of ventricular arrhythmias by the combination of Quinine and Adenosine. Supraventricular tachyarrhythmia [BC81] [96]
Pomalidomide DMTGBAX Moderate Decreased clearance of Quinine due to the transporter inhibition by Pomalidomide. Systemic sclerosis [4A42] [25]
Fostamatinib DM6AUHV Moderate Decreased clearance of Quinine due to the transporter inhibition by Fostamatinib. Thrombocytopenia [3B64] [97]
Lusutrombopag DMH6IKO Moderate Decreased clearance of Quinine due to the transporter inhibition by Lusutrombopag. Thrombocytopenia [3B64] [98]
Apixaban DM89JLN Moderate Decreased clearance of Quinine due to the transporter inhibition by Apixaban. Thrombosis [DB61-GB90] [37]
Lenvatinib DMB1IU4 Moderate Increased risk of prolong QT interval by the combination of Quinine and Lenvatinib. Thyroid cancer [2D10] [28]
Papaverine DMCA9QP Major Increased risk of prolong QT interval by the combination of Quinine and Papaverine. Tonus and reflex abnormality [MB47] [99]
Tizanidine DMR2IQ4 Moderate Increased risk of prolong QT interval by the combination of Quinine and Tizanidine. Tonus and reflex abnormality [MB47] [28]
Sirolimus DMGW1ID Moderate Increased plasma concentrations of Quinine and Sirolimus due to competitive inhibition of the same metabolic pathway. Transplant rejection [NE84] [90]
Tacrolimus DMZ7XNQ Moderate Increased plasma concentrations of Quinine and Tacrolimus due to competitive inhibition of the same metabolic pathway. Transplant rejection [NE84] [90]
Tolbutamide DM02AWV Moderate Increased risk of hypoglycemia by the combination of Quinine and Tolbutamide. Type 2 diabetes mellitus [5A11] [29]
Chlorpropamide DMPHZQE Moderate Increased risk of hypoglycemia by the combination of Quinine and Chlorpropamide. Type 2 diabetes mellitus [5A11] [29]
Insulin-detemir DMOA4VW Moderate Increased risk of hypoglycemia by the combination of Quinine and Insulin-detemir. Type-1/2 diabete [5A10-5A11] [29]
Insulin degludec DMPL395 Moderate Increased risk of hypoglycemia by the combination of Quinine and Insulin degludec. Type-1/2 diabete [5A10-5A11] [29]
Elagolix DMB2C0E Moderate Increased metabolism of Quinine caused by Elagolix mediated induction of CYP450 enzyme. Uterine fibroid [2E86] [33]
Astemizole DM2HN6Q Major Decreased metabolism of Quinine caused by Astemizole mediated inhibition of CYP450 enzyme. Vasomotor/allergic rhinitis [CA08] [100]
Trimeprazine DMEMV9D Moderate Increased risk of prolong QT interval by the combination of Quinine and Trimeprazine. Vasomotor/allergic rhinitis [CA08] [82]
Procainamide DMNMXR8 Major Increased risk of prolong QT interval by the combination of Quinine and Procainamide. Ventricular tachyarrhythmia [BC71] [28]
Amiodarone DMUTEX3 Major Increased risk of prolong QT interval by the combination of Quinine and Amiodarone. Ventricular tachyarrhythmia [BC71] [28]
⏷ Show the Full List of 245 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG
DIG Name DIG ID PubChem CID Functional Classification
Fumaric acid E00420 444972 Acidulant; Antioxidant; Complexing agent; Flavoring agent; Solubilizing agent
Sodium lauryl sulfate E00464 3423265 Emulsifying agent; Modified-release agent; Penetration agent; Solubilizing agent; Surfactant; lubricant
Ammonia E00007 222 Alkalizing agent
Calcium stearate E00244 15324 lubricant
Carmellose sodium E00625 Not Available Disintegrant
Eisenoxyd E00585 56841934 Colorant
Ferric hydroxide oxide yellow E00539 23320441 Colorant
Ferrosoferric oxide E00231 14789 Colorant
Lactose monohydrate E00393 104938 Binding agent; Diluent; Dry powder inhaler carrier; Lyophilization aid
Magnesium stearate E00208 11177 lubricant
Potassium hydroxide E00233 14797 Alkalizing agent
Povidone E00667 Not Available Binding agent; Coating agent; Disintegrant; Film/membrane-forming agent; Solubilizing agent; Suspending agent
Propylene glycol E00040 1030 Antimicrobial preservative; Humectant; Plasticizing agent; Solvent
Saccharose E00091 5988 Binding agent; Coating agent; Cryoprotectant; Diluent; Flavoring agent; Suspending agent; Viscosity-controlling agent
Silicon dioxide E00670 Not Available Anticaking agent; Opacifying agent; Viscosity-controlling agent
Sodium alginate E00671 Not Available Binding agent; Disintegrant; Suspending agent; Viscosity-controlling agent
Talc E00520 16211421 Anticaking agent; Diluent; Glidant; lubricant
Titanium dioxide E00322 26042 Coating agent; Colorant; Opacifying agent
Triacetin E00080 5541 Humectant; Plasticizing agent; Solvent
Zinc stearate E00209 11178 lubricant
⏷ Show the Full List of 20 Pharmaceutical Excipients of This Drug
Pharmaceutical Formulation
Formulation Name Drug Dosage Dosage Form Route
Quinine 300 mg tablet 300 mg Extended Release Oral Tablet Oral
Quinine 324 mg capsule 324 mg Oral Capsule Oral
Quinine 324 mg tablet 324 mg Extended Release Oral Tablet Oral
Quinine 200 mg tablet 200 mg Oral Tablet Oral
Quinine 300 mg tablet 300 mg Oral Tablet Oral
Jump to Detail Pharmaceutical Formulation Page of This Drug

References

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